Mechanisms of Cytotoxicity of the AIDS Virus.

Abstract

Regulatory genes of HIV-1, HIV-2, and SIV are important in modulating virus infection and infection and transmission in vivo. Viral proteins R (VPR) and X (VPX) and the negative factor (NEF) are three of the least well characterized regulatory proteins. Identification of their functions, their mechanisms of action and structure-function relationships of each protein, in vitro and in vivo will assist in our understanding of the pathogenesis of HIV induced disease. This information will be critical in defining therapeutic approaches to suppressing HIV-1 infection, replication, and transmission. Vpr, Vpx, Nef, HIV-1, Vpu, RA I, Cytotoxicity, Cellular Immunity, AIDS, HIV.

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Document Details

Document Type
Technical Report
Publication Date
Oct 10, 1991
Accession Number
ADA251630

Entities

People

  • Lee Ratner

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Biomedical And Dental Materials
  • Blood
  • Cells
  • Chemistry
  • Culture Techniques
  • Diseases And Disorders
  • Fatty Acids
  • Genetic Code
  • Infection
  • Lymphocytes
  • Materials
  • Molecular Biology
  • Monocytes
  • Polymeric Films
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology