Phosphatidylhydroxyalkanols as Versatile Intermediates in the Synthesis of Headgroup Modified Diacetylenic Phospholipids.

Abstract

Phospholipase D extract (from savoy cabbage) mediates exchanges of omega hydroxyalkanols (n = 2-4) with the choline moiety of phosphatidylcholines to produce corresponding phosphatidylhydroxyalkanols in > 70% yield. The phosphatidyl hydroxyalkanol and its chloro analogue were further reacted with molecules containing carboxylic and amine functionality respectively, providing an easy and efficient method to produce headgroup modified phospholipids. (Author)

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Document Details

Document Type
Technical Report
Publication Date
May 15, 1992
Accession Number
ADA251721

Entities

People

  • Alok Singh
  • Li-i Tsao
  • Michael Markowitz

Organizations

  • United States Naval Research Laboratory

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Alcohols
  • Alkenes
  • Amines
  • Anhydrides
  • Buffers (Chemistry)
  • Chemical Reactions
  • Chemical Shifts
  • Chlorides
  • Chromatography
  • Magnetic Resonance
  • Mass Spectra
  • Materials
  • Military Research
  • Silica Gels
  • Spectra

Fields of Study

  • Chemistry

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  • Organic Chemistry
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