New Therapeutic Modalities of Retinal Laser Injury.

Abstract

Efficacies of three different regimens of high dose of methylprednisolone (MP) treatment on laser-induced non-hemorrhage retinal injury and tissue plasminogen activator (t-PA) in sub-retinal hemorrhage laser injury were evaluated in a sub-human primate model and a rat model respectively. Clinical, histopathological, and morphometric criteria were employed for evaluating the efficacy of MP. High dose and prolonged treatment (4 days) was the most effective regimen while high dose for 8 hours showed limited effect in non-hemorrhagic retinal injury. Intravitreal t-PA showed no apparent beneficial effect in sub-retinal hemorrhage after laser injury. Hence, patients with laser retinal injury may benefit from high dose MP treatment for an appropriate period of time. Laser, Retina, Injury, Treatment, Corticosteroids, Methylprednisolone, tissue plasminogen activator, sub-retinal hemorrhage, RA 3.

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 1992
Accession Number
ADA251871

Entities

People

  • Mark O. Tso
  • Tim T. Lam

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular System
  • Cells
  • Central Nervous System
  • Chemistry
  • Epithelial Cells
  • Hemorrhage
  • Intercellular Junctions
  • Laser Beams
  • Laser Safety
  • Measurement
  • Medical Personnel
  • Nervous System
  • Retinal Diseases
  • Spinal Injuries
  • Therapy
  • Yag Lasers

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Pulsed Power and Plasma Physics.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Directed Energy