Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds.

Abstract

N-methyl-, n-ethyl- and n--butyl-2nitratoethyl nitramine (MENENA, EtNENA and BuNENA) and bis (2,2-dinitropropyl) acetal/formal (-50/50 mixture) +/- diphenyl amine stabilizer (BDNPA/F+/-DPA) were tested for dermal toxicity. One group of ten rabbits per study received the test article once by topical application and was held in contact with the skin for 24 hours. Animals were observed for clinical signs and mortality daily for 14 days. One animal receiving BDNPA/F-DPA died during the study. No mortality was observed in any other treatment groups. Based upon the results of these assays, the estimated acute dermal LD50 for MeNENA, EtNENA, BuNENA and BDNPA/F+/-DPA, was determined to be greater than 2000 mg/kg.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1992
Accession Number
ADA252109

Entities

People

  • Victor T. Mallory
  • Vincent B. Ciofalo

Tags

DTIC Thesaurus Topics

  • Amines
  • Animals
  • Bandages
  • Biomedical Research
  • Body Weight
  • Intestines
  • Laboratory Animals
  • Management Personnel
  • Materials
  • Metal Matrix Composites
  • Nitramines
  • Observation
  • Propellants
  • Recombinant Dna
  • Research Facilities
  • Test And Evaluation
  • Test Facilities

Readers

  • Toxicology/Environmental Toxicology