Biannual Progress Report Number 1, Grant Number N00014-92-J-1113 (Materials Research Society, Pittsburgh, PA).

Abstract

Since the project was funded we have purchased a Sun SPARCStation 2, which has arrived and been outfitted with the necessary software for carrying out the computer modeling studies. A search for an appropriate postdoctoral fellow has begun, but none has been identified so far. We have applied our personnel funds by employing one of the existing postdoctoral fellows in the laboratory part time on the project (he may become so interested as to convert completely to this project, which would be a satisfactory end to our search). In addition, we have employed a technician who has been assigned to the patch clamp studies funded as a part of the project. The experimental studies, whose goal is to gain quantitative descriptions of ionic conductances of neostriatal spiny neurons suitable for use in a computer model of the neuron, are making rapid progress. We were able to bring this aspect of the project up to speed quickly by taking advantage of an already active research program on modulation of ionic conductances by the neuromodulators dopamine and acetylcholine.

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Document Details

Document Type
Technical Report
Publication Date
May 20, 1992
Accession Number
ADA252320

Entities

People

  • Christopher K. Wilson

Organizations

  • Materials Research Society

Tags

DTIC Thesaurus Topics

  • Computer Simulations
  • Computers
  • Dopamine
  • Experimental Data
  • Experimental Design
  • Kinetics
  • Linear Systems
  • Materials
  • Membrane Potentials
  • Membranes
  • Modulation
  • Neurotransmitter Agents
  • Potassium
  • Recovery
  • Sensitivity
  • Simulations

Readers

  • Neuroscience
  • Research Science/Academic Research
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology