Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds.

Abstract

Bis (2,2-dinitropropyl) acetal/formal (-50/50 mixture) +/diphenyl amine stabilizer (BDNPA/F+/-DPA) were tested for oral toxicity. Groups of ten rats per dose level were fasted and administered the test article orally by gavage. Animals were observed for clinical signs and mortality at 1 and 4 hours after dosing and once daily for 14 days. Based upon the results of these assays, the definitive acute oral LD50 (combined sexes) for BDNPA/F+DPA was determined to be 4791.1 mg/kg with 95% confidence limits of 3057.7 to 7507.2 mg/kg. The definitive acute oral LD50 for BDNPA/F-DPA was determined to be 3718.3 mg/kg with 95% confidence limits of 3311.2 to 4175.3 mg/kg. Oral toxicity, unicharge, propellants, bis-(2,2-dinitropropyl) acetal, bis-(2,2-dinitropropyl) formal, lab animals, RA III.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1992
Accession Number
ADA252339

Entities

People

  • Victor T. Mallory
  • Vincent B. Ciofalo

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Body Weight
  • Confidence Limits
  • Environmental Protection
  • Intestines
  • Laboratory Animals
  • Lethal Dosage
  • Management Personnel
  • Materials
  • Propellants
  • Range Finding
  • Recombinant Dna
  • Research Facilities
  • Test And Evaluation
  • Test Facilities
  • Toxicity

Readers

  • Toxicology/Environmental Toxicology