An Investigation Concerning the Potential for use of Polylactic/Polyglycolic Acid Confluent Sheets in the Treatment of Osseous Defects,

Abstract

Polylactic/polyglycolic acid combinations (alpha polyamides) are biodegradable materials commonly used in suture materials and surgical meshes for the temporary support of abdominal organs. The materials are well known in the clinical literature and have been in common usage without risk for over two decades. The polyamides are rich in polyester linkages that are degraded in aqueous environments by hydrolysis. Various investigators have shown that the pure form of polyglycolic acid (PGA) degrades over a period of 5 months whereas pure polylactic acid (PLA) takes about 6.5 months. Copolymers of PLA/PGA have been synthesized that degrade within a few weeks to several months depending upon the ratios employed and the specific sequencing of the chemical units. Further, the alpha polyamides show no adverse host tissue reactions when implanted in numerous animal models.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADA252769

Entities

People

  • Caesar E. Solano
  • Charles M. Cobb
  • John C. Reed
  • Robert W. Hiatt

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bones
  • Cells
  • Connective Tissue
  • Dura Mater
  • Giant Cells
  • Health Services
  • Materials
  • Osteogenesis
  • Prostheses And Implants
  • Prosthetics
  • Surgery
  • Surgical Implantation
  • Time Intervals
  • Tissues
  • Wounds And Injuries

Readers

  • Polymer Science and Engineering.
  • Systems Analysis and Design
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Microelectronics