Histologic Evaluation of a Polylactic Acid Confluent Sheet in the Treatment of Osseous Defects,
Abstract
Polylactic and polyglycolic acids(alpha polyamides) or combinations thereof are biodegradable materials commonly used in suture materials and surgical meshes for the temporary support of abdominal organs. The materials are well known in the clinical literature and have been in common usage without risk for over two decades. The polyamides are rich in polyester linkages that are degraded in aqueous environments by hydrolysis. Various investigators have shown that the pure form of polyglycolic acid (PGA) degrades over a period of 5 months whereas pure polylactic acid (PLA) takes about 6.5 months. copolymers of PLA/PGA have been synthesized that degrade within a few weeks to several months depending upon the ratios employed and the specific sequencing of the chemical units. Further, the alpha polyamides show no adverse host tissue reactions when implanted in numerous animal models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADA252770
Entities
People
- Caesar E. Solano
- Charles M. Cobb
- John C. Reed
- W. R. Hiatt