Isolation Suppresses Both Immune and Neuroendocrine Functioning and Decreases the Locomotor Activity of Normal and Immunosuppressed C3H/HeN Mice
Abstract
This inter-disciplinary experiment examined the dramatic influence that environmental variables can have on behavioral, neuroendocrine, and immune system parameters. In this study, we examined the effects of housing on locomotion, circulating lymphocytes, and catecholamines (i.e., Norepinephrine N and Epinephrine E) of 12-week-old female C3H/HeN mice. Ten week old female C3H/HeN mice (10/group) were either immunocompromised (following 0.5 Gy or 4.5 Gy 60Co gamma irradiation) or normal (sham-irradiated), and were housed in isolation (1/cage) or groups (10/cage) for 25 days following radiation exposure. All dependent variables were obtained on day 25 postirradiation. Isolation, Immune System, Neuroendocrine, Locomotor activity, Immunosuppression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 15, 1992
- Accession Number
- ADA253183
Entities
People
- Dale F. Gruber
- Daniel L. Collins
- G. A. Mickley
- Michelle M. D'alesandro
- Stuart J. Cohen
Organizations
- Armed Forces Radiobiology Research Institute