Testing of Experimental Compounds for Efficacy Against Leishmania.
Abstract
A total of 1,684 compounds was studied for antileishmanial activity against Leishmania donovani in hamsters. Ninety of these had some suppressive activity, five had activity greater than the reference compound, Glucantime, five had activity approximately equal to that of Glucantime, and the remainder were less active than Glucantime. Several chemical classes including 8- aminoquinolines, purine analogs, quinolines, pyridines, heavy metal complexes, berberine derivatives, and pyrazine or quinazoline inhibitors of dihydrofolate reductase, were among those compounds tested. Some of the 8-aminoquinolines as well as some of the purine analogs were among the most active compounds studied but many were toxic. Quinolines, pyridines, and heavy metal complexes (for example sulfonamides) were active while pyrazine or quinazoline inhibitors of dihydrofolate reductase were generally inactive. Three berberine derivatives had some activity against L. donovani but were generally toxic and less active than Glucantime. Leishmania donovani, WRO6026, RA 1, chemotherapy, berberine, pyrimidine nucleotides, golden hamster, sinefungin, synergistic studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 1990
- Accession Number
- ADA253305
Entities
People
- Virginia B. Waits
- William L. Hanson
- Willie L. Chapman Jr.
Organizations
- University of Georgia Research Foundation