Evaluation of Chemotherapeutic Agents Against Malaria, Drugs, Diet, and Biological Response Modifiers.
Abstract
In the primary blood schizonticidal test 1 105 compounds were evaluated and 39 exhibited antimalarial activity.Dihydroartemisinin cured all mice when administered in a total dose of 100 mg/kg given PO for 4 days (D+O, 1, 2 and 3) at 12 hr intervals. A 50 mg/kg total dose administered in a similar regimen cured only 1 of 10 m i ce when administered PO at 8 hr intervals for 5 days (D+O, 1, 2, 3 and 4) . A total dose of 60 mg/kg of Na artelinate and Na artesunate were inactive while dihydroartemisinin at 240 mg/kg was curative. Two tetraoxanes (BM 07749 and BM 07721) given PO on days 3, 4 and 5 cured all mice at 640 and 1280 mg/kg/day. Transdermal applications of artemisinin and 3 analogs in a prophylactic regimen (D+O, 1 and 2) or a curative regimen (D+3, 4 and 5) showed dihydroartemisinin to be the most active followed by artelinic acid, methyl artelinate and artemisinin. All of the transdermal drugs had penetrated by 30 minutes as judged by cleaning the treated area with alcohol. In the Thompson test 35 experiments were performed to assess suppressive and curative activity of compounds against drug-sensitive lines resistant or lines resistant to either qinghaosu, WR 238605, mefloquine, chloroquine, pyrimethamine or quinine. Vitamin E; Lab Animals; Rodents; RAI; Malaria; Plasmodium; Anti- Oxidants; Pro-Oxidants; Glucan.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 29, 1991
- Accession Number
- ADA253315
Entities
People
- Arba L. Ager Jr.
Organizations
- University of Miami