Drug Evaluation in the Plasmodium Falciparum - Aotus Model.
Abstract
The Panamanian Aotus - Plasmodium falciparum model was used to evaluate potential antimalaria drugs. Neither protriptylene nor tetrandrine, each administered with chloroquine, was effective in reversing chloroquine, resistance of Vietnam Smith/RE infections. Promethazine, administered twice daily, with chloroquine was no more effective in reversing chloroquine- resistance than when administered once daily. The absence of antimalarial activity of chlorpromazine and prochlorperazine confirmed previous studies in which in vivo reversal of chloroquine resistance was attributed to each of these drugs plus chloroquine. A bisquinoline, WR 268668, was inactive against Smith/RE infections, possibly due to lack of absorption. A water soluble form of the drug is scheduled to be evaluated. RAI; Malaria; P. Falciparum; Aotus Monkey; Antimalarial; Drug Evaluation; Lab Animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 23, 1992
- Accession Number
- ADA253528
Entities
People
- Richard N. Rossan