Synaptic Plasticity and Memory Formation.
Abstract
Work conducted during AFOSR-89-0383 indicates that long-term potentiation is induced and stabilized by variants of the chemistries that regulate adhesive relationships. Expression of the potentiation effect involves modification of a subgroup of post-synaptic receptors; this modification includes a change in the kinetics of the receptor's ion channel. New evidence linking long-term potentiation to memory was obtained during the tenure of the grant and pharmacological agents that promote its occurrence were identified. Based on this information, attempts to design and synthesize memory enhancing drugs have been initiated. The following paragraphs briefly describe these developments and cite relevant publications; a fuller description is found in the application for continuation of AFOSR support.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 14, 1992
- Accession Number
- ADA253904
Entities
People
- Gary Lynch
Organizations
- University of California, Irvine