World Reference Center for Arboviruses.
Abstract
The major finding in 1991 was the discovery of a new arenavirus Guanarito, causative agent of Venezuelan hemorrhagic fever. The study of 15 patients in Portuguesa State, Venezuela confirmed the clinical syndrome of hemorrhagic fever, and the high case fatality rate (9/15). Serological diagnostic tests were developed including IgM capture ELISA. Initial observations in the field indicated a probable rodent-borne epidemiology. Other findings included a new genotype of Japanese encephalitis virus in Indonesia, and the development of recombinant vaccinia viruses excreting subviral particles that immunized mice to Japanese encephalitis and yellow fever viruses. The reference center distributed arboviral reagents to laboratories in the United States and in 9 other countries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 08, 1992
- Accession Number
- ADA254096
Entities
People
- Robert E. Shope
Organizations
- Yale University