Longterm Follow-Up of Patients in CSP 298 'Treatment of Patients with Acquired Deficiency Syndrome (AIDS) and AIDS Related Complex'.

Abstract

In order to determine whether there is a long-term benefit to initial versus delayed treatment with AZT, a long-term follow-up study is being conducted for patients enrolled in a USAMRDC funded, randomized trial of early versus later zidovudine (AZT) therapy in patients with symptomatic HIV infection and CD4 counts between 200 and 500 cells/cmm. At the present time, the study demonstrates no survival benefits, no reduction in the number or rate of progression to AIDS, no improvements in the quality of life in one or the other treatment arm, and some emergence of low level resistance in patients treated with AZT for more than one year. These studies are continuing with approximately 73% of the original study population. RA 1; A2T; Drug Trials; HIV; Veterans; Follow-up.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1992
Accession Number
ADA254508

Entities

People

  • Jonathan Hamilton
  • M. S. Simberkoff

Organizations

  • Veterans Administration Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Infective Agents
  • Base Lines
  • Data Analysis
  • Deficiencies
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Health Services
  • Hiv Infections
  • Infection
  • Materials
  • Quality Of Life
  • Resistance
  • Survival
  • Therapy
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Immunology
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Technical Research and Report Writing.