Host Factors Contributing to Disability Following Sulfur Mustard Exposure
Abstract
Cytokines are autocrine and paracrine protein hormones produced by cells in response to specific and nonspecific stimuli. They play a major role in both acute and chronic inflammatory processes, including those produced by sulfur mustard (SM). Understanding of the role of cytokines in SM lesions should lead to better therapy because various cytokine activators and inhibitors are becoming available. In situ hybridization of the mRNA of various cytokines with radiolabeled antisense RNA probes enables us to visualize under the microscope which cells in tissue sections of SM lesions are producing which type of cytokine. This technique, therefore, demonstrates cell function histologically, even though the cells are no longer alive at the time of analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 30, 1992
- Accession Number
- ADA255301
Entities
People
- Arthur M.
Organizations
- Johns Hopkins University