Cholinergic Neurotransmission in the Mammalian Retina.

Abstract

The cholinergic cells in the retina consist of matching subpopulations of amacrine and displaced amacrine cells which ramify narrowly in the inner plexiform layer (IPL). Previous cytochemical studies revealed that the hydrolytic enzyme acetylcholinesterase (AChE), which terminates the action of acetylcholine (ACh), is more widespread in its distribution than the enzyme choline acetyltransferase (ChAT), which is responsible for ACh synthesis. Cytochemical techniques were utilized to further define the sites of cholinergic interaction in the retina. Autoradiographic studies showed that both the muscarinic receptor ligand (3H)propylbenzilyl choline mustard and the putative nicotinic receptor ligand (3H)alpha-bungarotoxin bind preferentially in the IPL. RAV; Lab animals; morphology; retina; neurotransmitters; acetylcholine; organophosphates; chemical defense.

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Document Details

Document Type
Technical Report
Publication Date
Jan 30, 1988
Accession Number
ADA255818

Entities

People

  • Roberta G. Pourcho

Organizations

  • Wayne State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Animals
  • Atropine
  • Cells
  • Central Nervous System
  • Classification
  • Computers
  • Enzymes
  • Hydrolysis
  • Laboratory Animals
  • Materials
  • Nerves
  • Nervous System
  • Neurons
  • Organophosphorus Compounds
  • Peptides
  • Poisoning

Fields of Study

  • Chemistry

Readers

  • Neuroscience
  • Neurotoxicology