The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident

Abstract

Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1992
Accession Number
ADA255936

Entities

People

  • Dennis V. Canfield
  • Jerry R. Hordinsky
  • Vicky L. White

Organizations

  • Federal Aviation Administration

Tags

Communities of Interest

  • Advanced Electronics
  • Air Platforms

DTIC Thesaurus Topics

  • Accidents
  • Aircrafts
  • Aviation Accidents
  • Aviation Medicine
  • Carbon Monoxide
  • Chromatographs
  • Chromatography
  • Detectors
  • Dielectric Gases
  • Extraction
  • Gas Chromatography
  • Gases
  • Identification
  • Liquid Chromatography
  • Liquids
  • Thin Layer Chromatography
  • United States

Readers

  • Aviation Safety Risk Assessment.
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology