Digital Vasculitis Associated With Interferon Therapy
Abstract
Several drugs have been shown to cause necrotizing vasculitis. When occlusion of the digital arteries of the hands occurs, the cause is usually small vessel disease rather than thromboembolic events. We report a patient who developed digital vasculitis after treatment with interferons. We add this form of toxicity to those known to be caused by interferons and emphasize such toxicity may be seen in patients who are receiving long-term interferon therapy. This complication is considered clinically important because long-term interferon therapy is used in the treatment of chronic hepatitis B infection, inflammatory and viral dermatoses, rheumatoid arthritis and with increasing frequency in hematologic malignancies such as CML, myeloma and non-Hodgkin's lymphoma. Interferon, vasculitis, chronic myelogenous leukemia.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1992
- Accession Number
- ADA256053
Entities
People
- Frederick A. Lombardo
- Howard Ozer
- James A. Coffey
- John Redmond Iii
- Sharon L. Hammond
- Thomas J. Reid Iii
Organizations
- Walter Reed Army Institute of Research