Evaluation of N-Methyl-n'-Nitroguanidine in Short-Term Genetic Toxicity Tests.

Abstract

N-Methyl-N'-nitroguanidine (MNG) is being considered as a component of Air Force explosive formulations. This chemical was evaluated in several bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonella/microsomal assay, the Chinese hamster ovary/hypoxanthine- guanine phosphoribosyltransferase forward mutation assay, and the mouse in vivo bone marrow micronucleus assay. Both in vitro assays were conducted in the presence and absence of S9 metabolic activation enzymes. The results of the three genetic tests indicated that MNG does not interact with genetic material. Also, no toxicity was observed for very high dose levels. These assays would therefore predict essentially no genotoxic risk from exposure to MNG. Ames Assay, Forward Mutation Assay, Genotoxicity, N-Methyl-N'-Nitroguanidine, Mouse Micronucleus Assay.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1991
Accession Number
ADA256270

Entities

People

  • A. Thilagar
  • C. S. Godin

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Animals
  • Bone Marrow Cells
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Contracts
  • Environmental Protection
  • Genetics
  • Governments
  • Mutagenicity Tests
  • Nitroso Compounds
  • Rodents
  • Test And Evaluation
  • Toxicity

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology