Pemoline and Methylphenidate: Interaction With Mood, Sleepiness, and Cognitive Performance During 64 Hours of Sleep Deprivation

Abstract

Moderate doses of methylphenidate or pemoline were tested for maintaining cognitive performance during sleep deprivation. Reductions in performance speed and accuracy were a function of both amount of prior wakefulness and hour of day, with greatest decrements between 0000 and 0600, especially the 2d night of sleep loss. At the doses used, pemoline was more effective than methylphenidate in countering the effects of sleep loss and the circadian cycle. Pemoline reduced subjective and objective sleepiness and improved performance speed on most tasks. Effects on accuracy were more variable. Sleep Deprivation, Cognitive Performance, Stimulants, Pemoline, Methylphenidate, Circadian Rhythms.

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Document Details

Document Type
Technical Report
Publication Date
Jul 07, 1992
Accession Number
ADA256601

Entities

People

  • A. Lopez
  • H. Babkoff
  • L. T. Mattseon
  • Salvador Gomez
  • T. L. Kelly

Organizations

  • Naval Health Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Rhythms
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Circadian Rhythms
  • Cognition
  • Data Storage Systems
  • Heart Rate
  • Information Processing
  • Information Science
  • Mental Processes
  • Nervous System
  • Pharmacology
  • Psychology
  • Reaction Time
  • Sleep Deprivation
  • Therapy
  • Vital Signs

Fields of Study

  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology