Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques.

Abstract

This project was put forth to meet the needs expressed by the Naval Medical Research and Development Command for long-term dried storage of human blood cells for transfusion support of combat casualty care. OUr main focus was on preparation of platelets for successful dehydration, storage, and rehydration without substantial compromise of hemostatic function. The primary technology was developed as an extension of a pre-existing protocol for drying fixed platelets as a diagnostic product, but many alternative approaches were also tried on an empirical basis. None of these methods had been previously applied to the development of a transfusion product.

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Document Details

Document Type
Technical Report
Publication Date
Nov 02, 1992
Accession Number
ADA257345

Entities

People

  • Arthur P. Bode
  • Marjorie S. Read
  • Robert L. Reddick
  • Stein Holme
  • W. A. Heaton

Organizations

  • East Carolina University

Tags

DTIC Thesaurus Topics

  • Albumins
  • Antigens
  • Blood
  • Blood Cells
  • Blood Coagulation
  • Blood Coagulation Factors
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Electron Microscopy
  • Freeze Drying
  • Microscopes
  • Microscopy
  • North Carolina
  • Patent Applications
  • Test And Evaluation

Readers

  • Immunology
  • Systems Analysis and Design
  • Trauma or Military Medicine