Effects of Dextromethamphetamine on Subjective Fatigue.

Abstract

Declining aircrew performance during periods of sustained flight operations (SUSOPs) has underscored the need to develop effective countermeasures. This paper reports on the ability of the central nervous system (CNS) stimulant d-methamphetamine to alleviate the detrimental effects of a simulated SUSOPs on subjective fatigue. Subjective fatigue was repeatedly measured by three questionnaires. The simulated SUSOP started at 1800 and consisted of a 9-h planning session followed by 4 h of rest and a 14-h mission. After 6 h of sleep, the 9/4/14 work/rest/work pattern was repeated. At 4 1/2 h into the second mission, 13 subjects were administered 10 mg of d- methamphetamine/70 kg of body mass while 12 subjects received a placebo in a double-blind procedure. Administration of d-methamphetamine significantly reduced reported fatigue scores on the Addiction Research Center Inventory (ARCI), Mood Questionnaire (MQ), and sleepiness scores on the Stanford Sleepiness Scale (SSS). Sustained Flight Operation, Countermeasures, Stimulant, D-Methamphetamine, Fatigue.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1992
Accession Number
ADA258252

Entities

People

  • C. A. Dejohn
  • D. F. Neri
  • S. A. Shappell

Organizations

  • Naval Aerospace Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Addiction
  • Biomedical Research
  • Central Nervous System
  • Countermeasures
  • Department Of Defense
  • Drug Abuse
  • Flight Simulators
  • Flight Training
  • Health Services
  • Inventory
  • Local Area Networks
  • Lysergic Acids
  • Nervous System
  • Questionnaires
  • Side Effects
  • Training

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Irregular Warfare and Special Operations Cyberspace Operations against Adversarial Threats.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.