Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Porcine Model. Subtitle: Effects of Pharmacologic and Immunologic Intervention on the Porcine Pseudomonas Model of Adult Respiratory Distress Syndrome (ARDS).
Abstract
Almost twenty-five years after Ashbaugh and Petty published their report of an explosive form of lung injury in critically ill patients, which they termed adult respiratory distress syndrome (ARDS), the mortality and morbidity from this condition remains essentially unchanged. ARDS continues to present a formidable clinical challenge to the clinician, whether in civilian or military practice. Approximately 150,000 cases per year are seen in the United States and it frequently affects young previously healthy patients. ARDS represents an extremely complex sequela to shock, sepsis, civilian or military trauma and a number of other conditions, of widely varying etiology, which have a common clinical presentation and pathophysiology as ARDS. The background to ARDS and the important role played by military ,medical personnel in first recognizing the association of severe trauma and infection with end-organ injury such as ARDS has been reviewed in a previous report from laboratory and will not be discussed here.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1992
- Accession Number
- ADA258476
Entities
People
- Alastair C. Windsor
- Alpha A. Fowler
- Harvey J. Sugerman
- Patrick G. Mullen
Organizations
- Virginia Commonwealth University School of Medicine