Diagnosis of Natural and Induced Diseases of Military Importance
Abstract
Physical optics Corporation (POC) has investigated a new diagnostic technology that can be directly applied to the detection of the AIDS antigen or antibody, unlike the current procedures which only detect antibodies to HI-V. POC's method is based on a highly sensitive ligand receptor, binding to its specific membrane receptor that is accompanied by conformational changes of the receptor protein which is followed by incorporating a fluorescent lipid probe into the target membrane. This provides a new opportunity for circumventing the well-known limitations of existing AIDS diagnostic tests which detect antibodies that confer non-protection, so all persons with antibodies are considered to have an active infection. In addition, a small percentage of infected persons have undetectable amounts of the antibody despite an established infection which is demonstrable by culturing the virus from tissues. Our proposed method of AIDS detection by polarization fluorometer for fluorescence anisotropy of lipid probe (PFFALP) offers direct proof of the presence of the AIDS virus.... AIDS, HIV, Immunoassay, RA I, PIV, Diagnostic test, Polarization fluorim, Peptide-Antibody.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1990
- Accession Number
- ADA259269
Entities
People
- Gajendra Savant