Preliminary Assessment of the Relative Toxicity of 1,5-Diazido-3- Nitrazapentane 90-Day Dermal Application Male and Female Rabbits Study Number 75-51-Y809-90, May 1990 - June 1992. Phase 2

Abstract

A 90-day application of DANPE has the potential to cause testicular hypospermatogenesis in male rabbits and an apparent inhibition of mature ovarian follicles formation in female rabbits. A no-observed-adverse-effect-level was not achieved in the male rabbits but was achieved in female rabbits at 27.3 mg/kg dose level.... 1,5-Diazido-3-Nitrazapentane, Dermal, Approximate Lethal Dose (ALD), Testicular hypospermatogenesis, Ovarian follicle No-observed-adverse- effect-level (NOAEL).

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1992
Accession Number
ADA259309

Entities

People

  • Everett A. Haight
  • John G. Harvey Jr.
  • Patricia Beall

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Blood
  • Blood Cells
  • Body Weight
  • Cells
  • Chemistry
  • Classification
  • Health
  • Lethal Dosage
  • Leukocytes
  • Lymphatic System
  • Materials
  • Medical Personnel
  • Rodents
  • Security
  • Toxicity

Readers

  • Toxicology/Environmental Toxicology