Combination Immunotherapy In Experimental Pseudomonas Sepsis
Abstract
Immunotherapy has been shown to be effective adjuvant in the management of septic shock. A neuropenic rat model of septic shock induced by infection with pseudomonas aeruginosa 12.4.4 was used to determine the relative efficacy of single, double, and triple combination immunotherapy. A Pseudomonas 0 serotype-specific, opsonophagocytic monoclonal antibody, polyclonal J5 antiserum and a Mab directed against tumor necrosis factor (TNF) were studied as single therapy and in combination of all three immunotherapeutic agents resulted in a 77% survival rate. This level of of protection was superior to that achieved with any combination of two antibody treatments or single antibody therapy or compared with the control group. Immunotherapy directed against multiple steps of the septic process is more active than single or double antibody regimens and may offer an improved approach to the adjunctive treatment of septic shock.... Sepsis, Immunotherapy, Pseudomonas infection, Tumor necrosis factor, LPS Core glycolipid.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA259375
Entities
People
- A. S. Cross
- J. E. Palardy
- Jerald Sadoff
- M. W. Bodmer
- S. M. Opal
Organizations
- Walter Reed Army Institute of Research