Diagnosis and Chemotherapy of Human Trypanosomiasis and Vector Ecology of Rift Valley Fever and Congo-Crimean Hemorrhagic Fever in Kenya

Abstract

This activity is Principally centered around work with the KETRI vervet Model and the Alupe Human Sleeping Sickness Referral Hospital at Busia. Over the last ten years, KETRI has been able to develop a primate model that closely mimics late stage human sleeping sickness. Application of this model for development and refinement of diagnostic and chemotherapeutic regimens is now in progress. By mid-term of this project, five potential compounds from Walter Reed Army Institute had been screened. Three of the compounds proved to have an efficacy that merits further investigation. Although no funds were specifically allocated for combination therapy the project reviewers recommended that the synergism reported between suramin and other drugs by other workers be investigated in the KETRI Vervet model. This work has started especially using DFMO and a combination of other drugs.... RA I, Volunteers, Hemorrhagic fever, Vectors, Trypanosomiasis, Rift valley fever, Lab animals, Monkey.

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Document Details

Document Type
Technical Report
Publication Date
Nov 06, 1991
Accession Number
ADA259524

Entities

People

  • J. K. Omuse

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Artificial Satellites
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Combination Therapy
  • Habitats
  • Health Services
  • Infection
  • Materials
  • Rift Valley Fever
  • Rift Valleys
  • Side Effects
  • Therapy
  • Ticks
  • Virus Diseases

Readers

  • Computational Modeling and Simulation
  • Parasitology and Pharmacology of Malaria.
  • Virology (or Medical Virology).