Synthesis and Antiviral Evaluation of N-Carboxamidine-Substituted Analogues of 1-Beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine Hydrochloride

Abstract

Ribavirin and its 3-carboxamidine hydrochloride analogue are broad- spectrum antiviral agents which were synthesized and developed nearly concurrently. Both compounds possess efficacy against a broad array of DNA and RNA viruses, are known inhibitors of inosine monophosphate dehydrogenase (IMP) after adenosine-kinase dependent conversion to nucleotides, and, in general, possess similar mechanisms of action. In addition to IMP dehydrogenase, 2A is an effective competitive inhibitor of purine nucleoside phosphorylase.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1992
Accession Number
ADA259559

Entities

People

  • Bjarne Gabrielsen
  • Cathy See
  • John W. Huggins
  • Luis Barthel-rosa
  • Michael J. Phelan

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Amines
  • Amino Acids
  • Antiviral Agents
  • Arbovirus Infections
  • Chemical Synthesis
  • Chemistry
  • Encephalitis
  • Interferon
  • Nucleosides
  • Organic Chemistry
  • Plastic Explosives
  • Rna Viruses
  • Two Dimensional
  • Virus Diseases
  • Viruses

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Parasitology and Pharmacology of Malaria.