Liquid Collagen Wound Coverings

Abstract

Sealing of flasks containing sterile lyophilized collagen, in plastic-lined foil pouches purged of atmospheric air which is replaced by dry nitrogen, has been successful. Recently, difficulties with lyophilization of sealed-up pouches has been a problem, specifically and unacceptable amount of 'meltback' leading to evaporation rather than sublimation. Collagen which has been subjected to 'meltback' fails to rehydrate in an acceptable manner. The Research Department at Oregon Freeze Dry will work to pinpoint and correct the cause of this problem. The successful use of a 'Gortex' membrane bag for lyophilization of blood products by Oregon Freeze Dry Research has given rise to the concept of a multichamber bag constructed on one side from the 'Gortex' membrane and on the other by clear impervious plastic to allow visual examination of the lyophilized and the rehydrated collagen. The final product is to be packaged in similar plastic-lined foil pouches with dry nitrogen replacing atmospheric air as presently used for flasks.

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Document Details

Document Type
Technical Report
Publication Date
Jan 14, 1993
Accession Number
ADA259702

Entities

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cartilage
  • Cells
  • Collagen
  • Combat Casualty Care
  • Freeze Drying
  • Growth Factors
  • Membranes
  • Military Research
  • Molecular Biology
  • Naval Operations
  • New Zealand
  • Nitrogen
  • Technical Information Centers
  • Tissue Culture
  • Tissues
  • Wound Healing

Readers

  • Gender and Food Studies
  • Immunology
  • Thermal Physics or Thermal Science.