Pyrodoxine Deficiency and Wound Healing in Rats: Assessment of Antioxidant Enzymes and Immunological Status,
Abstract
Many nutrients are involved in the complex process of wound healing. Of the vitamins, pyridoxine (vitamin B6) deficiency has resulted in impaired healing, primarily due to its effect on amino acid and protein metabolism. This study examined the effects of pyridoxine deficiency on wound healing and its effects on acute phase proteins, immunoglobulins, and antioxidant enzymes in rats. Female rats were fed diets containing 0 mg/kg (deficient), 0.25 or 1.0 mg/kg (marginally deficient) or 7 mg/kg (control) pyridoxine for 5 weeks. Half the animals in each dietary group received a 3 cm long full skin incisional wound on the back and all animals were euthanized 1 week later. The results showed that despite pyridoxine deficiency, the animals in each dietary group had similar acute phase responses and antioxidant enzyme status in response to the injury... .Pyridoxine, Wound healing, Antioxidant, Rats, Immunoglobulins
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1992
- Accession Number
- ADA259960
Entities
People
- Michael A. Dubick
- Thornton S. Mu
Organizations
- Letterman Army Hospital