Vascular Abnormalities Associated with Thermal and Electrical Trauma,
Abstract
Exposure of tissue to temperatures in excess of 43 deg C results in cell injury and cell death due to the direct effects of heat as well as the effects of humoral mediators secreted by the endocrine system and liberated by the injured tissues, The net result of these changes is edema formation due to an increase in capillary filtration representing the summation of altered microvascular pressures and increased microvascular permeability. The magnitude of edema formation secondary to these microvascular changes is large enough to result in significant hypovolemia in burns that involve more than 25% of the total body surface area. Pitt et al., in studies of microvascular, hemodynamic, and permeability changes in a canine hind paw model of scald injury, found that, during the first 3 hr following burn injury, increased capillary pressure, as indexed by a 74% decrease in pre-to postcapillary vascular resistance, accounted for 53% of the increase in capillary filtration. In those studies, increased permeability accounted for 47% of the increase in early postburn capillary filtration, with 49% of the microvascular filtrate passing through large, 500-A nonsieving pores.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADA260587
Entities
People
- Basil A. Pruitt Jr.
- William G. Cioffi Jr.
Organizations
- United States Army Institute of Surgical Research