The Acute Inhalation Toxicity of Pyrolysis Products of Halon 1301
Abstract
To develop exposure systems and methodology to deliver pure, stable atmospheres of Hf, HBr, or HCl to laboratory rats. To determine the toxicological equivalency of inhaled HF, HBr, and HCl in the upper and lower respiratory tract. Characterize the anatomical sites of injury caused by HF, HCl, and HBr when inhaled at high mass concentrations through the nasal (NB) and oral (MB) pathways. To assess the relative toxicities of the above halides when inhaled at high mass concentrations during mouth and nose breathing. To characterize the upper and lower respiratory tract lesion(s) produced by HCl inhalation in the nose breathing (NB) and mouth breathing (MB) rats during CO2- induced increased minute ventilation. To examine the toxicity of HF when administered directly into the rat's lung. To determine if work performance incapacitation occurs after acute high concentration inhalation of HCl via the nose (NB) or the mouth (MB). To assess post-exposure exercise as a potentiator of the severity of expression of halide-induced respiratory tract injury. To initiate studies to determine whether or not lung injury becomes more pronounced after halides are breathed in combination with a particulate phase.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1992
- Accession Number
- ADA260874
Entities
People
- Bruce E. Lehnert
Organizations
- Los Alamos National Laboratory