Development of a Controlled Release Delivery System for Immunogens
Abstract
The development program addresses the problem of effectively protecting military personnel from bacterial, viral, or toxic incapacitation. At the present, logistical problems in carrying out a protective program remain formidable because vaccination programs involve: multiple injections; administration by trained medical personnel; and careful medical record maintenance. An approach to reducing the 'Logistical problems is to modify immunization formulations so that single doses confer complete immunity. The overall program goal is to demonstrate that immunity comparable to that obtained with an initial vaccination plus one booster vaccination can be obtained by simultaneous injection of normal and sleeper vaccine formulations. In Phase I of the program, prototype formulations demonstrated the feasibility of three important facets of the of sleeper concept. One formulation (which did not contain protein) showed that, when subjected to a moist environment, it could remain almost unchanged for about 6 weeks, at which point it rapidly swelled and released many small particles. Another prototype, containing protein, showed delayed protein release properties; and yet a third formulation was used to demonstrate retention of antigenic conformation after processing and exposure to moisture for two weeks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 15, 1990
- Accession Number
- ADA260987
Entities
People
- Judith P. Kitchell