Quantitative Structure-Activity Relationships of Chlorinated Alicyclic Compounds.
Abstract
The project, which was designed to conduct a quantitative structure- activity relationship study on a series of chlorinated alicyclic compounds (a number of which are insecticides or their metabolites or degradation products) was initiated, with the neurochemical characterization being conducted at Mississippi State University and the physicochemical characterization being conducted at Iowa State University. Experiments quantified the inhibitory potency of the compounds for the binding of 35S-t-butylbicyclophosphorothionate (TBPS), which binds to the gamma-aminobutyric acid (GABA) receptor, the target for the test compounds. A wide range of potencies were discovered (IC50's of 4. 2-22,734 nM), which correlated well with acute toxicity levels. NMR analysis of the compounds has been run and the molecular connectivity calculations have been initiated....Chlorinated alicyclic compounds, QSAR, GABA Receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 1993
- Accession Number
- ADA261258
Entities
People
- Janice E. Chambers
Organizations
- Mississippi State University