Analysis of Neural Systems Involved in Modulation of Memory Storage
Abstract
The aims of this research project were to investigate the involvement of opiate and GABAergic systems, in different brain regions, in regulating the storage of memory for different types of tasks. The proposed experiments were based on previous findings providing extensive evidence that memory storage is influenced by treatments affecting neuromodulatory systems in the amygdala as well as preliminary evidence suggesting the possibility that such influences might be limited to restricted domains (or forms) of learning and memory. The view that GABAergic and opiate drugs act by influencing memory storage is supported by previous, as well as recent evidence that the drugs do not induce state-dependency. That is, the effects on retention performance do not depend upon a congruence between drug states at the time of training (or shortly after training) and retention testing. The research supported by this grant has provided additional evidence that memory storage is influenced by opiate and GABAergic influences. Within the range of tasks examined, the effects did not depend upon the forms of learning and memory examined. Both the amygdala and septum appear to be involved in regulating GABAergic influences on memory and the effects appear to be mediated through cholinergic influences.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1993
- Accession Number
- ADA262418
Entities
People
- James L. Mcgaugh
Organizations
- University of California, Irvine