In Vivo Distribution of Liposome Encapsulated Hemoglobin Studied with Imaging Radiotracers

Abstract

This project has as its objective the development of radiotracer imaging technology to follow the in vivo circulation and organ deposition of liposome encapsulated hemoglobin (LEH). LEH will be labeled with technetium-99m (99m Tc) or indium-111 (111In) and infused into small animals to monitor any in vivo differences between different LEH formulations. These studies will be correlated with any hematological and pathological changes associated with LEH treatment. Development of such non-invasive monitoring techniques may lead to significant cost effective manufacturing and formulation improvements, and ultimately a more efficacious LEH product. The development of this elegant labeling technique should make it possible to study the effect of various LEH modifications on biodistribution non-invasively in primates and humans.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 29, 1993
Accession Number
ADA262533

Entities

People

  • William T. Phillips

Organizations

  • University of Texas at San Antonio

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Blood Groups
  • Blood Substitutes
  • Blood Volume
  • Body Weight
  • Bone Marrow
  • Clearances
  • Heart Rate
  • Hemoglobin
  • Imaging Techniques
  • Materials
  • Positron Emission Tomography
  • Positron Emissions
  • Resuscitation
  • Synthetic Membranes
  • Tissues

Readers

  • Aerospace Engineering
  • Medical Imaging.