Tracheobronchial Mucins in Health, Disease, and Toxic Exposures
Abstract
The major portion of this project, identification of mucin core peptide, raising the antibody against mucin peptide, mucin gene expression in rat tracheal epithelial culture system, has been successfully accomplished. The main discovery in this project is the role of retinoic acid (a component of vitamin A) in maintaining healthy tracheal epithelial cells exposed to different toxic and carcinogenic substances, and use of steroids in suppression of mucin gene expression. Further studies are underway to discern the mechanism involving the role of vitamin A in mucin gene expression in the tracheal epithelial cell system. The environmental research facility and exposure chamber have been completed. Experiments relating to exposure will begin shortly. The last portion of the project could not be accomplished due to the delay in the contracting procedures relating to construction of the environmental facility and exposure chamber.... RA 2, Inhalation toxicology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1993
- Accession Number
- ADA262974
Entities
People
- Sambhu N. Bhattacharyya
Organizations
- William Beaumont Army Medical Center