Effects on Chronic Stress on Anterior Pituitary and Brain Corticotropin- Releasing Factor Receptors,
Abstract
125I corticotropin-releasing factor ({125I}CRF) binding was measured in membrane homogenates from anterior pituitary and 8 brain regions from control and chronically stressed rats. The stressor consisted of 3 or 14 days of around-the-clock intermittent footshock avoidance/escape (ITI = 5 min) . Plasma corticosterone levels were almost doubled in stressed rats following 3 days of chronic stress and remained significantly elevated in rats stressed for 14 days vs. controls. {125I}CRF binding was decreased in anterior pituitary and frontal cortex following three days of chronic stress; binding affinity of anterior pituitary membranes was not different between control and stressed animals. {125I}CRF binding was similar in control and 3 day stressed animals in the other brain areas examined. After 14 days of chronic stress, hypothalamic {125I}CRF binding was decreased in stressed rats as compared to control animals but no other differences were seen.... Stress, Corticotropin-releasing factor receptors, CRF, CRH, Corticotropin-releasing hormone, Neuroendocrine factor receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA263177
Entities
People
- Errol B. De Souza
- G. J. Kant
- Sally M. Anderson
Organizations
- Walter Reed Army Institute of Research