Molecular Studies of Alphavirus Immunogenicity
Abstract
In the past 6 months we have completed the sequences of Whataroa virus and Aura virus, and these sequences are being assembled into the complete sequences of the genomic RNAs. These two viruses are both closely related to Sindbis virus, and Sindbis-like viruses have now been shown to occur throughout the temperate and tropical world except for North America. Aura virus may have served as the ancestral virus that was transmitted to the Old World to found the Sindbis-like viruses present throughout the Old World. It may Also have served as one of the parents of Western equine encephalitis virus, which arose by recombination between Eastern equine encephalitis virus and a New World virus related to Sindbis virus. In this project we have also developed methods to use high throughout automated sequencing in order to rapidly obtain sequence data for entire viral RNA genomes.... Alphavirus, Sindbis virus, Whataroa virus, Aura virus BD, Epitopes, Immunogenetics, DNA, BL2, Biotechnology, RA 4.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 03, 1992
- Accession Number
- ADA264058
Entities
People
- James Strauss
Organizations
- California Institute of Technology