Measurement of the Magnetic and Electrical Activity of Individual Cells In Vitro
Abstract
This report describes the development of both incoherent and coherent fiber optic sensors for monitoring the electrical activity of cells and tissue. The incoherent sensors use an optical fiber to deliver laser light to a cell membrane that is stained with a voltage-sensitive dye. The change in resulting fluorescence allows the electrical activity of the cell to be monitored. The coherent fiber sensor uses an external element, either a cell or some other material that has induced birefringence, as an extrinsic sensing element. The fiber is a means for delivering coherent light to this element. Birefringence- induced phase changes are detected in a heterodyne interferometric scheme. This report also describes the development work to date on NanoSQUID, a very small scale, superconducting quantum interference device that will allow spatially- resolved measurements of the magnetic activity of cells and tissue. Fiber optic sensors, SQUID magnetometers, Voltage-sensitive dyes, Cellular electrical activity, RA 3.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 26, 1993
- Accession Number
- ADA264517
Entities
People
- Christopher C. Davis
Organizations
- University of Maryland