Comparison of Beta-Artemether and Beta-Arteether against Malaria Parasites In Vitro and In Vivo
Abstract
The antimalarial activity of Beta-artemether and Beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P. berghei, and in Aotus monkeys infected with chloroquine-resistant P. falciparum. In vitro, the mean 50% inhibitory concentration (IC50) for Beta-artemether was 1.74 nM (range 1.34-1.81 nM), and this value for Beta-arteether was 1.61 nM (range 1.57-1.92 nM). They were approximately 2.5-fold more potent than artemisinin, which had a mean IC50 of 4.1 1 nM (range 3.36-4.60 nM). In the mouse model, the 50% curative doses (CD50) of Beta-artemether and Beta-arteether had a mean value of 55 mg/kg (32-78 mg/kg). The 50% effective curative doses (ED50) in the Aotus monkey were 7.1 mg/kg (95% confidence interval (CI) = 3.7- 13.5) for Beta-artemether and 11.8 mg/kg (95% CI = 6.5-21.3) for Beta-arteether. Overall, the activities of the two drugs were comparable....Comparison, Beta- Artemether, Beta-Arteether, Malaria parasites in vitro, Malaria parasites in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA264519
Entities
People
- Daniel L. Klayman
- Dennis E Kyle
- Moshe J. Shmuklarsky
- Richard N. Rossan
- Wilbur K. Milhous
Organizations
- Walter Reed Army Institute of Research