T Cell Recognition of Mls-like Superantigens: Analysis of TCR requirements, Superantigenic Ligands, and Signal Transduction
Abstract
Mls-like endogenous superantigens have been reported to be unique, differing from conventional antigens in the T cell receptor (TCR) requirements for their recognition, in the signal transduction events which they elicit in T cells, and in the identity of the stimulatory ligand. This review describes recent findings indicating that TCR V(alpha) as well as V(beta) products play a role in mls recognition. Data are also summarized which indicate that T cell recognition of Mls leads to increased intra-cellular (Ca2(+)) and phosphatidyl inosotol hydrolysis. Finally, genetic linkage between mouse mammary tumor virus (MMTV) proviruses and endogenous superantigens is analyzed, and the possible role of non-MMTV products is examined.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1992
- Accession Number
- ADA264779
Entities
People
- Richard J. Hodes
- Ryo Abe
Organizations
- Naval Medical Research Center