Lipid Dependent Mechanisms of Protein Pump Activity

Abstract

The objectives of the grant were to investigate the relationship between the activity of membrane proteins, such as pumps and channels, and the elastic curvature properties of the imbedding lipid bilayer. The goal was to understand if the lipid composition affects protein activity via a coupling to the bilayer elastic constants. The specific objectives were; To develop experimental methods of measuring membrane elastic properties and the interaction with proteins; To correlate protein pump activity and channel activity with membrane elastic properties; To investigate the relationship between lipid composition and the spontaneous curvature of native membranes.

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Document Details

Document Type
Technical Report
Publication Date
Apr 29, 1993
Accession Number
ADA264848

Entities

People

  • Sol M. Gruner

Organizations

  • Princeton University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Chemistry
  • Couplings
  • Diffraction
  • Elastic Properties
  • Geometry
  • High Pressure
  • Lipids
  • Measurement
  • Membrane Lipids
  • Membrane Proteins
  • Neutron Diffraction
  • Phase Transformations
  • Physical Theories
  • Transitions
  • X Rays
  • X-Ray Diffraction

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