Synergistic Roles of Interleukin-6, Interleukin-1, and Tumor Necrosis Factor in the Adrenocorticotropin Response to Bacterial Lipopolysaccharide in Vivo

Abstract

Administration of lipopolysaccharide (LPS) results in activation of the hypothalamic-pituitary-adrenal axis. LPS induces the release of a number of proinflammatory cytokines, I.E. interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF), which activate the hypothalamic-pituitary-adrenal axis as well and may mediate the effects of LPS. Variations in the kinetics of appearance of IL- 1, TNF, and IL-6 after LPS challenge suggested that these cytokines may play different roles at different times. To elucidate the mutual dependence and contribution of individual cytokines in the course of LPS-induced ACTH release, we used blocking antibodies to IL-6, TNF, and the IL-1 receptor.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1993
Accession Number
ADA265343

Entities

People

  • Edward H. Mougey
  • John S. Abrams
  • Mark H. Whitnall
  • Robert S. Perlstein
  • Ruth Neta

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Bacterial Infections
  • Biological Factors
  • Brain
  • Cells
  • Cellular Structures
  • Chemistry
  • Endocrine Glands
  • Hormones
  • Laboratory Animals
  • Macrophages
  • Nervous System
  • Neurosecretory Systems
  • Peptide Growth Factors
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology