NMR Binding Studies of Monosaccharides to Cholic Acid Hosts

Abstract

Synthetic molecular receptors have been prepared by linking two cholic acid moieties with p-xylylene diamine, m-xylylene diamine, or diphenyldichlorosilane. In-depth studies of the p-xylyl and m-xylyl hosts binding with n-pentylglucoside have been carried out by means of 600 MHz NMR. Using CDCl3 as solvent, chemical shift changes have been observed for H3 and H4 of the glucoside. Data suggest that the glucoside can bind to all cholic acid dimers studied so far, and also to cholic acid monomers used for comparison

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1991
Accession Number
ADA265581

Entities

People

  • Cynthia J. Burrows
  • Ruey-fen Liao

Organizations

  • Stony Brook University

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Bile
  • Carbohydrates
  • Chemical Shifts
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Dermatologic Agents
  • Glycosides
  • Hydrogen Bonds
  • Macrocyclic Compounds
  • Molecules
  • Monosaccharides
  • Organic Chemistry
  • Recognition
  • Security
  • Sugars

Fields of Study

  • Chemistry

Readers

  • Aquatic Ecology
  • Organic Chemistry