Role of Spatially Distributed Ion Channels in Single Neuron Computation

Abstract

Towards the overall goal of making an accurate mathematical model of a neocortical pyramidal neuron, (1) the electrical properties of Na+ and Ca2+ channel subtypes were measured in sufficient detail to construct a quantitative empirical model, and (2) antibodies were raised against the a1 subunits of these channel subtypes in order to determine their spatial distribution and relative density using quantitative immunocytochemistry.... Ion channels, Sodium, Calcium, Electrophysiology, Immunocytochemistry

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Document Details

Document Type
Technical Report
Publication Date
May 17, 1993
Accession Number
ADA265972

Entities

People

  • Peter C. Schwindt

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Brain
  • Cell Line
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Computations
  • Confocal Microscopy
  • Electrical Properties
  • Ionic Current
  • Mathematical Models
  • Models
  • Nervous System
  • Neurosciences
  • Spatial Distribution
  • Voltage

Readers

  • Computational Modeling and Simulation
  • Molecular and Cellular Biochemistry
  • Neuroscience