Resuscitation from Hypovolemia in Swine with Intraosseous Infusion of a Saturated Salt-Dextran Solution (SSD)
Abstract
Prehospital fluid resuscitation of traumatic injury is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near saturated salt-dextran solution (SSD) administered through a new device which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady state baseline, all animals were hemorrhaged to 45 mmHg for one hr. Half of the hemorrhaged animals were then treated with a 10-30 minute Io infusion of either normal saline (NS) or SSD until cardiac output was restored to baseline. No further infusion was given and animals were monitored for 2 hrs. Both regimens were able to restore cardiac output to baseline, but only 1.3 + or - 0.1 mL/kg of SSD was required vs. 31.6 + or - 6.3 mL/kg for NS. Intraosseous, Dextran-70, Hypertonic saline, Resuscitation, Hypovolemia, Pigs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1992
- Accession Number
- ADA266428
Entities
People
- C. B. Clifford
- D. E. Runyon
- George C. Kramer
- M. A. Dubick
- S. P. Bruttig
Organizations
- Letterman Army Hospital