Evaluation of Hemoglobin-Oxygen Equilibrium Binding by Rapid-Scanning Spectrophotometry and Singular-Value Decomposition

Abstract

A review of a new method to measure oxygen equilibrium binding to hemoglobin solutions by rapid-scanning spectrophotometry is presented. State-of- the-art technologies are reviewed and compared. The new method is based on rapid-scanning spectrophotometry that is used to resolve directly unique optical transitions during continuous hemoglobin oxygenation. Mathematical techniques for matrix multicomponent analysis and singular value decomposition (SVD) are described, and spectral artifacts that are resolved by these sensitive techniques are discussed. Hemoglobin-oxygen binding, Rapid-scanning spectrophotometry, Singular value decomposition.

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Document Details

Document Type
Technical Report
Publication Date
Mar 08, 1993
Accession Number
ADA266453

Entities

People

  • Kim D. Vandegriff
  • Richard I. Shrager

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Artifacts
  • Chemical Reactions
  • Complex Mixtures
  • Curve Fitting
  • Decomposition
  • Dissociation
  • Gas Flow
  • Hemoglobin
  • Measurement
  • Oxygen Electrodes
  • Oxygenation
  • Proteins
  • Scanning
  • Spectra
  • Spectrophotometry
  • Spectroscopy
  • Transitions

Readers

  • Linear Algebra
  • Medical Imaging.
  • Thin Film Deposition Science.