Increased Vascular Resistance with Hemoglobin-Based Oxygen Carriers
Abstract
Purpose: To compare the effects of resuscitation with hemoglobin- based oxygen-carriers and conventional crystalloid and colloid resuscitation fluids on hemodynamics, oxygen transport, and oxygen consumption in an animal model of the field medical use of these fluids in the treatment of hemorrhagic shock. Protocol: Twenty-eight immature swine were surgically prepared, allowed to recover five days, water deprived for 48 hours, hemorrhaged of 25 m1/kg over one hour, resuscitated promptly with 1) Ringer's lactate, 75 m1/kg, 2) 7% albumin in Ringer's acetate, 25 m1/kg, 3) 9% unmodified hemoglobin in Ringer's acetate, 25 ml/kg, or 4) 9% alpha alpha-crosslinked hemoglobin in Ringer's acetate, 25 ml/kg, observed with three hours of hemodynamic and oxygen transport measurements, and, finally, blood which had been removed previously was returned.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA266454
Entities
People
- C. S. Gomez
- J. R. Hess
- V. Copper
- V. W. Macdonald